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A Practical Guide to Metabolomics Applications in Health and Disease: From Samples to Insights into Metabolism

Posted By: AvaxGenius
A Practical Guide to Metabolomics Applications in Health and Disease: From Samples to Insights into Metabolism

A Practical Guide to Metabolomics Applications in Health and Disease: From Samples to Insights into Metabolism by Julijana Ivanisevic, Martin Giera
English | PDF EPUB (True) | 2024 | 445 Pages | ISBN : 3031442555 | 89.5 MB

This well-accessible textbook constitutes a practical guide to metabolomics approaches and applications in an integrative manner.

Mechanisms of Mineralization of Vertebrate Skeletal and Dental Tissues

Posted By: AvaxGenius
Mechanisms of Mineralization of Vertebrate Skeletal and Dental Tissues

Mechanisms of Mineralization of Vertebrate Skeletal and Dental Tissues by Irving M. Shapiro , William J. Landis
English | PDF EPUB (True) | 513 Pages | ISBN : 3031343026 | 153 MB

The book presents a multi-disciplinary approach to understanding mechanisms regulating the formation of mineral in vertebrate skeletal and dental tissues. The focus of the book is directed toward the mineralization process, an evolutionarily conserved system in which cells synthesize a complex and unique extracellular matrix into which mineral is deposited. Regulatory control is viewed though lenses that emphasize the genetic, physical-chemical, biochemical, structural, cellular and extracellular aspects of the mineralization process as they relate to crystal nucleation, growth and maturation. Throughout the book, defects in regulation at the genetic and transcriptional levels are linked to the numerous clinical problems associated with the mineralization of bone, cartilage, tendon, tooth, and soft tissues.

Advances in Pharmacokinetics and Pharmacodynamics

Posted By: AvaxGenius
Advances in Pharmacokinetics and Pharmacodynamics

Advances in Pharmacokinetics and Pharmacodynamics by Panos Macheras
English | PDF EPUB (True) | 2023 | 208 Pages | ISBN : 3031295404 | 23.3 MB

This book provides a concise overview of recent advances in Pharmacokinetics (PK) and Pharmacodynamics (PD). The pharmacokinetics section covers the state of the art in Physiologically Based Pharmacokinetic (PBPK) modeling (Chapter 1) as well as the assessment of food effect on drug absorption using PBPK modeling (Chapter 2). Chapters 3 and 4 describe the recent development of Physiologically Based Finite Time Pharmacokinetic (PBFTPK) models and their applications to pharmacokinetic data. The pharmacodynamics section focuses on PK/PD modeling. Chapter 5 provides an overview of PK/PD modeling and simulation in clinical practice and studies. Chapter 6 deals with the subject/physiology variability issue encountered in PK/PD studies, while Chapter 7 reviews the influence of clinical pharmacology in the modernization of drug development and regulation. This book is an essential reference for pharmaceutical scientists.

Integrative Human Biochemistry: A Textbook for Medical Biochemistry, Second Edition (Repost)

Posted By: AvaxGenius
Integrative Human Biochemistry: A Textbook for Medical Biochemistry, Second Edition (Repost)

Integrative Human Biochemistry: A Textbook for Medical Biochemistry, Second Edition by Andrea T. Da Poian
English | EPUB | 2021 | 685 Pages | ISBN : 3030487393 | 197.3 MB

This book covers in detail the mechanisms for how energy is managed in the human body. The basic principles that elucidate the reactivity and physical interactions of matter are addressed and quantified with simple approaches. Three-dimensional representations of molecules are presented throughout the book so molecules can be viewed as unique entities in their shape and function.

Tissue Engineering: From Lab to Clinic

Posted By: AvaxGenius
Tissue Engineering: From Lab to Clinic

Tissue Engineering: From Lab to Clinic by Norbert Pallua, Christoph V. Suscheck
English | PDF (True) | 2011 | 632 Pages | ISBN : 3642028233 | 33.59 MB

Tissue engineering is a multidisciplinary field incorporating the principles of biology, chemistry, engineering, and medicine to create biological substitutes of native tissues for scientific research or clinical use. Specific applications of this technology include studies of tissue development and function, investigating drug response, and tissue repair and replacement. This area is rapidly becoming one of the most promising treatment options for patients suffering from tissue failure. This abundantly illustrated and well-structured guide serves as a reference for all clinicians and researchers dealing with tissue engineering issues in their daily practice.

mRNA Vaccines

Posted By: AvaxGenius
mRNA Vaccines

mRNA Vaccines by Dong Yu, Benjamin Petsch
English | PDF,EPUB | 2023 | 215 Pages | ISBN : 3031180690 | 5.9 MB

The formulation and the technological advancements in RNA biology, chemistry, stability, and encapsulated delivery systems that have enabled the development of fully synthetic mRNA vaccines are discussed in this volume. The applications of the mRNA technology is covered, focusing on infectious diseases but also touching on other indications, such as immunotherapies and molecular therapies. Potent and long-lasting immune responses observed in animal models, encouraging data from early human clinical studies, together with the success of two mRNA-based COVID-19 vaccines support the use of mRNA-based vaccination as an attractive alternative to conventional vaccine approaches.

Therapeutic Proteins Against Human Diseases

Posted By: AvaxGenius
Therapeutic Proteins Against Human Diseases

Therapeutic Proteins Against Human Diseases by Fahmida Khatoon Zahid Balouch
English | PDF,EPUB | 2022 | 178 Pages | ISBN : 9811678960 | 19.9 MB

This book compiles updated research about the implications of therapeutic proteins in various human diseases. The initial chapters of the book provide basic information on the therapeutic proteins and discuss techniques for their formulation, production, and analytic approaches for their characterization. The subsequent chapters shed light on therapies based on therapeutic proteins against metabolic disorders, neurological disorders, cancer, autoimmune disorders, and infectious diseases. Importantly, it presents the factors influencing the immunogenicity of therapeutic proteins, including, genetic factors, disease type, and origin of therapeutic protein, dose frequency, administration route, and treatment duration.

Point-of-Care Solution for Osteoporosis Management: Design, Fabrication, and Validation of New Technology (Repost)

Posted By: AvaxGenius
Point-of-Care Solution for Osteoporosis Management: Design, Fabrication, and Validation of New Technology (Repost)

Point-of-Care Solution for Osteoporosis Management: Design, Fabrication, and Validation of New Technology by Patricia Khashayar
English | PDF | 2017 | 212 Pages | ISBN : 3319550527 | 6.5 MB

This book addresses the important clinical problem of accurately diagnosing osteoporosis, and analyzes how Bone Turnover Markers (BTMs) can improve osteoporosis detection. In her research, the author integrated microfluidic technology with electrochemical sensing to embody a reaction/detection chamber to measure serum levels of different biomarkers, creating a microfluidic proteomic platform that can easily be translated into a biomarker diagnostic. The Osteokit System, a result of the integration of electrochemical system and microfluidic chips, is a unique design that offers the potential for greater sensitivity. The implementation, feasibility, and specificity of the Osteokit platform is demonstrated in this book, which is appropriate for researchers working on bone biology and mechanics, as well as clinicians.

The Extracellular Matrix and the Tumor Microenvironment

Posted By: AvaxGenius
The Extracellular Matrix and the Tumor Microenvironment

The Extracellular Matrix and the Tumor Microenvironment by Ilona Kovalszky
English | PDF | 2022 | 493 Pages | ISBN : 3030997073 | 10.5 MB

This book introduces the most important and best studied extracellular and pericellular molecules of the tumor microenvironment. It gives a comprehensive overview of their role in tumor development and cancer progression.

Formulating Poorly Water Soluble Drugs, Third Edition

Posted By: AvaxGenius
Formulating Poorly Water Soluble Drugs, Third Edition

Formulating Poorly Water Soluble Drugs, Third Edition by Robert O. Williams III
English | EPUB | 2022 | 701 Pages | ISBN : 3030887189 | 79.4 MB

The objective of this third edition is to consolidate within a single text the most current knowledge, practical methods, and regulatory considerations pertaining to formulations development with poorly water-soluble molecules. A pharmaceutical scientist’s approach toward solubility enhancement of a poorly water-soluble molecule typically includes detailed characterization of the compound’s physiochemical properties, solid-state modifications, advanced formulation design, non-conventional process technologies, advanced analytical characterization, and specialized product performance analysis techniques. The scientist must also be aware of the unique regulatory considerations pertaining to the non-conventional approaches often utilized for poorly water-soluble drugs.

Phytocannabinoids: Unraveling the Complex Chemistry and Pharmacology of Cannabis sativa (Repost)

Posted By: AvaxGenius
Phytocannabinoids: Unraveling the Complex Chemistry and Pharmacology of Cannabis sativa (Repost)

Phytocannabinoids: Unraveling the Complex Chemistry and Pharmacology of Cannabis sativa by A. Douglas Kinghorn
English | PDF | 2017 | 137 Pages | ISBN : 3319455397 | 4.1 MB

The book presents the current state of the art on phytocannnabinoid chemistry and pharmacology and will be of much use to those wishing to understand the current landscape of the exciting and intriguing phytocannabinoid science. The focus is on natural product cannabinoids which have been demonstrated to act at specific receptor targets in the CNS.

Formulating Poorly Water Soluble Drugs, Third Edition

Posted By: AvaxGenius
Formulating Poorly Water Soluble Drugs, Third Edition

Formulating Poorly Water Soluble Drugs, Third Edition by Robert O. Williams III
English | PDF | 2022 | 701 Pages | ISBN : 3030887189 | 23.9 MB

The objective of this third edition is to consolidate within a single text the most current knowledge, practical methods, and regulatory considerations pertaining to formulations development with poorly water-soluble molecules. A pharmaceutical scientist’s approach toward solubility enhancement of a poorly water-soluble molecule typically includes detailed characterization of the compound’s physiochemical properties, solid-state modifications, advanced formulation design, non-conventional process technologies, advanced analytical characterization, and specialized product performance analysis techniques. The scientist must also be aware of the unique regulatory considerations pertaining to the non-conventional approaches often utilized for poorly water-soluble drugs.

Terapia genica

Posted By: AvaxGenius
Terapia genica

Terapia genica by Mauro Giacca
Italiano | PDF | 2011 | 253 Pages | ISBN : 8847019885 | 6 MB

Questo volume presenta, in maniera comprensiva e dettagliata e allo stesso tempo accessibile, l’intero settore della terapia genica, partendo dalle proprietà dei diversi geni terapeutici per finire con i risultati delle sperimentazioni cliniche più avanzate,e includendo la descrizione delle principali tecniche per il trasferimento genico in vivo ed ex vivo.

Artificial Organ Engineering (Repost)

Posted By: AvaxGenius
Artificial Organ Engineering (Repost)

Artificial Organ Engineering by Maria Cristina Annesini
English | PDF | 2017 | 271 Pages | ISBN : 1447164423 | 6.6 MB

Artificial organs may be considered as small-scale process plants, in which heat, mass and momentum transfer operations and, possibly, chemical transformations are carried out. This book proposes a novel analysis of artificial organs based on the typical bottom-up approach used in process engineering. Starting from a description of the fundamental physico-chemical phenomena involved in the process, the whole system is rebuilt as an interconnected ensemble of elemental unit operations.

Physician's Guide to the Diagnosis, Treatment, and Follow-Up of Inherited Metabolic Diseases, Second Edition

Posted By: AvaxGenius
Physician's Guide to the Diagnosis, Treatment, and Follow-Up of Inherited Metabolic Diseases, Second Edition

Physician's Guide to the Diagnosis, Treatment, and Follow-Up of Inherited Metabolic Diseases, Second Edition by Nenad Blau
English | EPUB(True) | 2022 | 1513 Pages | ISBN : 3030677265 | 95.7 MB

This updated and enlarged second edition is a unique source of information on the diagnosis, treatment, and follow-up of metabolic diseases.