This handbook reviews the clinical applications of stem cell-based therapy. The book covers the clinical applications of stem cells in cardiovascular diseases, neurological and ocular diseases, pediatrics, and the role of cancer stem cell-derived exosomal microRNA payload in lung cancer. The chapter reviews emerging stem cell therapy and tissue engineering approaches in neurodegenerative diseases. The book further examines the applications of stem cells in various fields of dentistry, and for the regeneration of oral and non-oral tissues. The chapters also explore the application of 3D bioprinting in conjunction with bone marrow mesenchymal stem cells for the treatment of bone defects and state-of-the-art technology for bone and cartilage regeneration using mesenchymal stem cells. The book presents stem cell-based therapy against renal, pancreatic, and kidney diseases and examines the advantages of a novel hepatic stem for cirrhotic liver repair and regeneration. Lastly, the book provides methodological and procedural advancements in stem cell-based therapy, including the applications of single-cell sequencing in stem cell research. This handbook is a major one-stop reference for researchers working in regenerative medicine, cellular pharmacology, stem cell research in general, and those involved in specific areas of adult stem cells as well as embryonic and induced pluripotent stem cells.

This book highlights the latest clinical research and advancements in 3D (bio)printing and 4D printing using stimulus-responsive hydrogels as well as the concept of self-healing and its amalgamation with 3D printed injectable cell-laden tissue constructs. It also explores the use of metal-free “click” chemistry and enzymes such as horseradish peroxidase, hematin, tyrosinase, and transglutaminase to obtain chemically crosslinked hydrogels and the in vitro and in vivo responses. Lastly, the book briefly examines the future of drug delivery and the potentials offered by microrobotics and self-powered devices based on triboelectric nanogenerators. This book caters to biomedical researchers and clinical practitioners working in tissue reconstruction and drug/therapeutic delivery.

This book reports on the latest research and developments in Biomedical Engineering, with a special emphasis on topics of interest and findings achieved in Latin America. This first volume of a 4-volume set covers advances in modeling and simulation of biological and biomedical systems, mechanical characterization, and biological evaluation of biomaterials for medical applications, including tissues regeneration. It also covers some related special topics, such as advanced methodologies for agricultural and food production and public health management. Throughout the book, a special emphasis is given to low-cost technologies and to their development for and applications in clinical settings. Based on the IX Latin American Conference on Biomedical Engineering (CLAIB 2022) and the XXVIII Brazilian Congress on Biomedical Engineering (CBEB 2022), held jointly, and virtually on October 24-28, 2022, from Florianópolis, Brazil, this book provides researchers and professionals in the biomedical engineering field with extensive information on new technologies and current challenges for their clinical applications.

The concept of regenerating tissues, with properties and functions that mimic natural tissues, has attracted significant attention in recent years. It provides potential solutions for treating many diseases and other healthcare issues. To fully realize the potential of the approach, it is crucial to have a rational biomaterial design to create novel scaffolds, and other materials systems suitable for tissue engineering, repair and regeneration. Research advances on the topic include the design of new biomaterials and their composites, the scaffold fabrication via subtractive and additive manufacturing approaches, the development of implantable scaffolds for disease monitoring, diagnostics, and treatment, as well as the understanding of cells-biomaterial scaffolds interaction.

This book highlights recent advances focusing on the synthesis methods of engineered biomaterials and their applications. The book discusses recent applications of various approaches and technology in improving the functional properties and biological activities of biopolymers. It includes two major sections: the first section introduces a range of methods which lead to materials with enhanced properties for a range of practical applications, along with the positives and limitations of the techniques. The second section covers recent trends and advances in application of engineered biomaterials that assist materials scientists and researchers in mapping out the future of these new improved materials through value addition in order to enhance their use. Contributions in the book are done by prominent researchers from industry, academia, and government/private research laboratories across the globe. The book summarizes in a fairly comprehensive manner many of the recent technical advancements in the area of biopolymers. The book is intended to serve as a reference resource in the area of polymers science.

This book reports on cutting-edge research and best practices in the broad fiel of biomedical engineering. Based on the XLVI Mexican Congress on Biomedical Engineering, CNIB 2023, held on November 2-4, 2023 in Villahermosa Tabasco, Mexico, this second volume of the proceedings covers research topics in biomechanics, materials and engineering design and manufacturing, with applications in prostheses design and development, tissue engineering, medical device assessment and healthcare management. All in all, this book provides a timely snapshot on state-of-the-art achievements in biomedical engineering and current challenges in the field. It addresses both researchers and professionals, and it is expect to foster future collaborations between the two groups, as well as international collaborations.

Only in recent years new available technologies, the redefinition and refining of intervention techniques, and clinical research studies have widened the spectrum of fat applications in aesthetic and reconstructive surgery. Fat grafting is nowadays one of the most used techniques in plastic reconstructive surgery, as primary method or as an ancillary procedure. The optimized ratio of fat survival has led to standardized techniques followed by most practitioners.

This book reviews the interface of stem cell biology and biomaterials for regenerative medicine. It presents the applications of biomaterials to support stem cell growth and regeneration. The book discusses the stem cell interactions’ with nanofiber, gradient biomaterial, polymer- and ceramic biomaterials, integrating top-down and bottom-up approaches, adhesive properties of stem cells on materials, cell-laden hydrogels, micro-and nanospheres, de-cellularization techniques, and use of porous scaffolds. Further, this book provides a basic introduction to the fabrication techniques for creating various biomaterials that can be used for stem cell differentiation.

Sustainable Material for Biomedical Engineering Application discusses current interdisciplinary approaches in the development of materials and their derivatives that are sustainable for biomedical engineering application. Recent advancement of materials research has shown to have great impact on biomedical and clinical applications. With potential for sustainability, the materials discussed and illustrated in this book, may have the ability to increase and contribute to wider therapeutic options for patients. On the other hand, with the advancement in materials technology, they also have positive impacts in terms of reproducibility and more cost-effective manufacturing solutions for biomedical engineering industry. Some of the main aspects covered in this book are utilisation of human waste, food waste and green technology approach for materials in biomedical engineering applications such as tissue engineering, 3D printing and biosensing. A team of experts from various disciplines share recent advances that provide details and integrates different approaches to sustainable materials development. This book is intended for academicians, researchers, students and industrial players in the field of materials and biomedical engineering.

Ninth volume of a 40 volume series on nanoscience and nanotechnology, edited by the renowned scientist Challa S.S.R. Kumar. This handbook gives a comprehensive overview about Nanotechnology Characterization Tools for Tissue Engineering and Medical Therapy. Modern applications and state-of-the-art techniques are covered and make this volume an essential reading for research scientists in academia and industry.

The concept of regenerating tissues, with properties and functions that mimic natural tissues, has attracted significant attention in recent years. It provides potential solutions for treating many diseases and other healthcare issues. To fully realize the potential of the approach, it is crucial to have a rational biomaterial design to create novel scaffolds, and other materials systems suitable for tissue engineering, repair and regeneration. Research advances on the topic include the design of new biomaterials and their composites, the scaffold fabrication via subtractive and additive manufacturing approaches, the development of implantable scaffolds for disease monitoring, diagnostics, and treatment, as well as the understanding of cells-biomaterial scaffolds interaction.

This book integrates the current basic and clinical knowledge in the area of biophysical stimulation of osteoblast for in vitro and in vivo live bone generation. This innovative methodology and its applications are presented and discussed in several clinical conditions: treatment of fracture nonunion, spine stabilization, bone replacement after tumor resections, stabilization of failed joint endoprostheses in revision surgery and in treatment of bone loss (osteoporosis and osteopenia).

This book provides an insight into the latest advances in bone fracture healing and remodeling algorithm and their incorporation into patient-specific finite element models and the use of machine learning and artificial intelligence to predict the bone regeneration and osseointegration process with a certain degree of accuracy. It also examines the applications of numerical models to simulate the fracture healing process, which may prove to be advantageous in determining the optimal mechanical-based treatment or reconstruction after an accident or illness. This book is aimed at medical and dental professionals who are involved in implantology and tissue engineering such as dentists, oral and maxillofacial surgeons, orthopedic surgeons, students, and researchers.

This book presents the latest findings in the field of cardiac mechanobiology in health and disease.
Cardiac mechanobiology provides knowledge of all aspects of mechanobiology of the heart. Cardiomyogenesis is discussed as well as the mechanobiology of cardiac remodeling and regeneration. The molecular mechanisms of mechanoperception and mechanotransduction in cardiomyocytes are explained, as well as stretch induced differentiation of cardiomyocytes derived from induced pluripotent stem cells.

The concept of regenerating tissues, with properties and functions that mimic natural tissues, has attracted significant attention in recent years. It provides potential solutions for treating many diseases and other healthcare issues. To fully realize the potential of the approach, it is crucial to have a rational biomaterial design to create novel scaffolds, and other materials systems suitable for tissue engineering, repair and regeneration. Research advances on the topic include the design of new biomaterials and their composites, the scaffold fabrication via subtractive and additive manufacturing approaches, the development of implantable scaffolds for disease monitoring, diagnostics, and treatment, as well as the understanding of cells-biomaterial scaffolds interaction.