Carbonic Anhydrase: Mechanism, Regulation, Links to Disease, and Industrial Applications by Susan C. Frost, Robert McKenna
English | PDF | 2014 | 429 Pages | ISBN : 9400773587 | 8 MB
The study of carbonic anhydrase has spanned multiple generations of scientists. Carbonic anhydrase was first discovered in 1932 by Meldrum and Roughton. Inhibition by sulfanilamide was shown in 1940 by Mann and Keilin. Even Hans Krebs contributed to early studies with a paper in 1948 showing the relationship of 25 different sulfonamides to CA inhibition. It was he who pointed out the importance of both the charged and uncharged character of these compounds for physiological experiments.