Four egocentric friends run a neighborhood Irish pub in Philadelphia and try to find their way through the adult world of work and relationships. Unfortunately, their warped views and precarious judgments often lead them to trouble, creating a myriad of uncomfortable situations that usually only get worse before they get better.

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Harley Quinn has finally broken things off once and for all with the Joker and attempts to make it on her own as the criminal Queenpin of Gotham City.