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Translational Research Methods in Neurodevelopmental Disorders

Posted By: AvaxGenius
Translational Research Methods in Neurodevelopmental Disorders

Translational Research Methods in Neurodevelopmental Disorders by Stéphane Martin, Frédéric Laumonnier
English | EPUB | 2022 | 271 Pages | ISBN : 1071625683 | 43.3 MB

This volume explores the latest techniques used to study neurodevelopmental diseases (NDD) that range from molecular aspects to integrated research approaches and brain imaging in living rodents. Chapters in this book cover topics such as protocols to deliver shRNA in vitro and in vivo using lentiviral particles to knock-down specific protein expression; experimental procedures to use recombinant fluorescent probes to visualize endogenous proteins at the mammalian synapse; CRISPR/Cas9 toolkit to assess either gain- or loss-of-gene function in brain organoids; detailed protocols to use in vivo manipulations to correct the behavioral phenotypes in cognitive disorder mouse lines; and experimental approaches to genetically engineer macaque models of NDDs and investigate how genetic predisposition may cause neural and functional alterations. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory.

Translational Research Methods in Neurodevelopmental Disorders

Posted By: AvaxGenius
Translational Research Methods in Neurodevelopmental Disorders

Translational Research Methods in Neurodevelopmental Disorders by Stéphane Martin, Frédéric Laumonnier
English | PDF | 2022 | 271 Pages | ISBN : 1071625683 | 9.4 MB

This volume explores the latest techniques used to study neurodevelopmental diseases (NDD) that range from molecular aspects to integrated research approaches and brain imaging in living rodents. Chapters in this book cover topics such as protocols to deliver shRNA in vitro and in vivo using lentiviral particles to knock-down specific protein expression; experimental procedures to use recombinant fluorescent probes to visualize endogenous proteins at the mammalian synapse; CRISPR/Cas9 toolkit to assess either gain- or loss-of-gene function in brain organoids; detailed protocols to use in vivo manipulations to correct the behavioral phenotypes in cognitive disorder mouse lines; and experimental approaches to genetically engineer macaque models of NDDs and investigate how genetic predisposition may cause neural and functional alterations. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory.

Organoid Technology for Disease Modelling and Personalized Treatment

Posted By: AvaxGenius
Organoid Technology for Disease Modelling and Personalized Treatment

Organoid Technology for Disease Modelling and Personalized Treatment by Badrul Hisham Yahaya
English | EPUB | 2022 | 209 Pages | ISBN : 3030930556 | 7.4 MB

Organoid Technology for Disease Modelling and Personalised Treatment provides a comprehensive overview of current knowledge of the organoid as a human-organ-in-a-dish, a powerful new technology for studying fundamental aspects of human organ development and disease progression in the search for drugs for personalised treatment. This preclinical tool is extensively being utilised as a model for studying human diseases in a dish, which is critical for accurate predictive modelling in precision medicine.

Cell Biology and Translational Medicine, Volume 14: Stem Cells in Lineage Specific Differentiation and Disease

Posted By: AvaxGenius
Cell Biology and Translational Medicine, Volume 14: Stem Cells in Lineage Specific Differentiation and Disease

Cell Biology and Translational Medicine, Volume 14: Stem Cells in Lineage Specific Differentiation and Disease by Kursad Turksen
English | EPUB | 2021 | 225 Pages | ISBN : 3030804917 | 10.6 MB

Much research has focused on the basic cellular and molecular biological aspects of stem cells. Much of this research has been fueled by their potential for use in regenerative medicine applications, which has in turn spurred growing numbers of translational and clinical studies. However, more work is needed if the potential is to be realized for improvement of the lives and well-being of patients with numerous diseases and conditions.

Cell Biology and Translational Medicine, Volume 14: Stem Cells in Lineage Specific Differentiation and Disease

Posted By: AvaxGenius
Cell Biology and Translational Medicine, Volume 14: Stem Cells in Lineage Specific Differentiation and Disease

Cell Biology and Translational Medicine, Volume 14: Stem Cells in Lineage Specific Differentiation and Disease by Kursad Turksen
English | PDF | 2021 | 225 Pages | ISBN : 3030804917 | 5.6 MB

Much research has focused on the basic cellular and molecular biological aspects of stem cells. Much of this research has been fueled by their potential for use in regenerative medicine applications, which has in turn spurred growing numbers of translational and clinical studies. However, more work is needed if the potential is to be realized for improvement of the lives and well-being of patients with numerous diseases and conditions.

Wheat Improvement: Food Security in a Changing Climate

Posted By: AvaxGenius
Wheat Improvement: Food Security in a Changing Climate

Wheat Improvement: Food Security in a Changing Climate by Matthew P. Reynolds
English | PDF,EPUB | 2022 | 657 Pages | ISBN : 3030906728 | 89.3 MB

This textbook provides a comprehensive, up-to-date guide for students and practitioners wishing to access in a single volume the key disciplines and principles of wheat breeding. Wheat is a cornerstone of food security: it is the most widely grown of any crop and provides 20% of all human calories and protein.

Resuscitation: Translational Research, Clinical Evidence, Education, Guidelines (Repost)

Posted By: AvaxGenius
Resuscitation: Translational Research, Clinical Evidence, Education, Guidelines (Repost)

Resuscitation: Translational Research, Clinical Evidence, Education, Guidelines by Antonino Gullo
English | EPUB | 2014 | 243 Pages | ISBN : 8847055067 | 1.7 MB

Resuscitation is a two-stage process comprising the achievement/maintenance of spontaneous circulation and post-resuscitation management. The approach is complex and multifaceted and entails the integration of new physiological insights, pharmacological options, and technological advances. The purpose of this volume, written by top experts in the field, is to promote, share, and disseminate new advances in resuscitation and post-resuscitation care.