Patch-Clamp Applications and Protocols (Neuromethods) by Alan A. Boulton
Patch-Clamp Applications and Protocols (Neuromethods) by Alan A. Boulton
English | May 1, 1995 | ISBN: 0896033112 | 323 Pages | PDF | 23 MB
English | May 1, 1995 | ISBN: 0896033112 | 323 Pages | PDF | 23 MB
E. Neher and B. Sakman were the first to monitor the opening and closing of single ion channels and membranes by conductance measurements. In 1976, they used firepolished micropipets with a tip diameter of 3-5 pm to record currents from a small patch of the membranbe of sk- etal muscles, thereby decreasing background membrane noise.