"Protein Phosphorylation in Human Health" ed. by Cai Huang

This book covers most important research hot points on protein phosphorylation and human health, such as Akt, AMPK and mTOR. Bridges the basic protein phosphorylation pathways with human health and diseases.

Contents
Preface
Section 1 Akt, mTOR and AMPK in Cancer and Metabolic Disorders
1 Protein Phosphorylation as a Key Mechanism of mTORC1/2 Signaling Pathways
2 Sestrins Link Tumor Suppressors with the AMPK-TOR Signaling Network
3 Regulation of Autophagy by Protein Phosphorylation
4 Fatty Acids Stimulate Glucose Uptake by the PI3K/AMPK/Akt and PI3K/ERK1/2 Pathways
Section 2 Protein Phosphorylation in Transcription, pre-mRNA Splicing and DNA Damage
5 RNA Polymerase II Phosphorylation and Gene Expression Regulation
6 The Prp4 Kinase: Its Substrates. Function and Regulation in Pre-mRNA Splicing
7 More Than Just an OFF-Switch: The Essential Role of Protein Dephosphorylation in the Modulation of BDNF Signaling Events
8 Signalling DNA Damage
Section 3 Tyrosine Protein Kinases in Receptor Signaling and Diseases
9 Tyrosine Phosphorylation of the NMDA Receptor Following Cerebral Ischaemia
10 Function of Flotillins in Receptor Tyrosine Kinase Signaling and Endocvtosis: Role of Tyrosine Phosphorylation and Oligomerization
11 Role of Tyrosine Kinase A Receptor (TrkA) on Pathogenicity of Clostridium perfringens Alpha-Toxin
12 Modulation of HER2 Tyrosine/Threonine Phosphorylation and Cell Signalling
Section 4 Protein Kinases and Phosphatases in Cell Cycle Regulation
13 Protein Phosphorylation is an Important Tool to Change the Fate of Key Players in the Control of Cell Cycle Progression in Saccharomyces
14 Phosphorylation Mediated Regulation of Cdc25 Activity, Localization and Stability
Section 5 Histidine Kinases in Two-Component Systems
15 Bacterial Two-Component Systems: Structures and Signaling Mechanisms