VEGF in Development (Molecular Biology Intelligence Unit)
VEGF in Development (Molecular Biology Intelligence Unit) by Christiana Ruhrberg
English | Apr. 21, 2008 | ISBN: 0387786317 | 116 Pages | PDF | 9 MB
English | Apr. 21, 2008 | ISBN: 0387786317 | 116 Pages | PDF | 9 MB
This book covers vascular endothelial growth factor A (VEGF or VEGFA), a secreted signaling protein. It highlights the central importance of this growth factor for vertebrate development. This book is devoted to vascular endothelial growth factor A (VEGF or VEGFA), a secreted signalling protein of great significance for development and disease in vertebrates. VEGFA controls the proliferation, migration, specialisation and survival of vascular endothelial cells, and it is therefore essential for the establishment of a functional blood vessel circuit. In addition, VEGFA is emerging as a versatile patterning factor for several non-endothelial cell types in vertebrates. Thus, it plays a central role during organ development at multiple levels, including blood vessel growth,vessel-mediated organ induction and tissue differentiation.